As Perricone states in his book The Acne Prescription, "Inflammation always comes first and it is the inflammation that is the cause of the clogged pore ..." His research points to the fact that acne is a systemic inflammatory disease that happens from the inside out.
These glands are located just below the skin surface. When sebum is produced in extra amount, hair follicles and pores become clogged. This clogging works towards blocking way used by dead cells to escape the skin. This sebum men and dead cells tend to allure attack from bacteria. This makes the surrounding tissues, to get inflamed and this result in acne.
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